Protamine neutralization factors for heparin. Thromb Res 1979 15: 191-197Īprotinin reduces clopidogrel-induced prolongation of the bleeding time in the rat. A comparison of different assay conditions in rats. Thromb Res 1989 54: 399-410īleeding time in laboratory animals II. Haemostasis 1996 26: 195-202Ĭomparison of two experimental thrombosis models in rats, effects of four glycosaminoglycans. Protamine sulfate inhibits pentasaccharide (SR 80027)-induced bleeding without affecting its antithrombotic and antifactor Xa activity in the rat. Pharmacological profile of the chemically synthesized antithrombin III binding fragment of heparin (pentasaccharide) in rats. Structure-activ-ity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity. Neutralization of the antithrombotic effects of heparin and fraxiparin by protamine sulfate. Neutralization of enoxaparine-induced bleeding by protamine sulfate. In vivo neutralization of low-molecular weight heparin fraction CY 216 by protamine. Incomplete reversal of enoxaparin-induced bleeding by protamine sulfate. Neutralization of a low molecular weight heparin (LHN-1) and conventional heparin by protamine sulfate in rats. Protamine titration after cardiopulmonary bypass. Hemorrhagic doses of heparin and other glycosaminoglycans induce a platelet defect. The present results suggest that protamine sulfate may be regarded as a potential antidote to neutralize bleeding side-effects in cases of SR 90107A/Org 31540 overdosing.Īntithrombotic and bleeding effects of glycosaminoglycans with different degrees of sulphation. However, protamine sulfate neither affected the anti-factor Xa activity nor the antithrombotic activity of SR 90107A/Org 31540 in rats and mice. It also neutralized the anti-factor Xa activity as well as the antithrombotic activity of heparin as observed in venous thrombosis models in both species. Protamine sulfate (10 mg/kg i.v.) reduced bleeding in rats and mice induced by both compounds. doses of 3 mg/kg heparin or 10 mg/kg SR 90107A/Org 31540. doses of 0.6 mg/kg heparin or 15 mg/kg SR 90107A/Org 31540 were required to enhance bleeding time to approximately the same extent (5- or 7-fold increase), whereas in mice a 13-fold increase in blood loss was observed with i.v. Bleeding, as measured by transection of the tail of anaesthetised rats or mice, was increased following the administration of heparin and very high doses of SR 90107A/Org 31540.
The neutralization by protamine sulfate of bleeding enhancement induced by the potent anti-factor Xa pentasaccharide SR 90107A/Org 31540 and by heparin has been studied in rats and mice. PDF Download Buy Article Permissions and Reprints Summary
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